Since Rogue EP control will disable endpoint learning on fast moving Mac addresses it might cause issues on endpoints that are currently moving a lot. By default a lot means more than 4 times in 60 seconds. This on a per leaf basis. So endpoint learning will be disabled on Leaf 1 if the Mac address moves more than 4 times in 60 seconds on that leaf. Another leaf switch might still be able to learn the endpoint.
To prevent issues it is possible since 5.2(3) to make exceptions for the Rogue EP control, so you can exclude certain Mac addresses in certain scenarios.
So in resume, enabling this setting might impact endpoints that are currently moving more than 4 times per 60 seconds (by default).
You can read more at: https://www.cisco.com/c/en/us/solutions/collateral/data-center-virtualization/application-centric-infrastructure/white-paper-c11-739989.html#RogueEPControl
