I have found the following information about deployment behind VPN WAN traffic encryption
does it also apply to other encryption soulitons such as Secunet SINA?
A WAAS device does not encrypt WAN traffic. If you require additional security measures, you should use a VPN. However, the VPN appliances must encrypt and decrypt traffic after and before the WAAS devices so that the WAAS device only sees unencrypted traffic. The WAAS device is unable to compress encrypted traffic and provides only limited TCP optimization to it.
Source: http://www.cisco.com/en/US/docs/app_ntwk_services/waas/waas/v421/configuration/guide/planning.html