DNAC will do a periodic resync (every 24 hours I think is the default but it can be changed) so that you don't need to worry about this. Yes, you can force a resync from inventory if you need to. That will read in the updated config.
FYI, in latest DNA versions, you can also change vlan and interface description by drilling down on a port after clicking the switch's hostname in inventory. That might trigger a resync immediately, I'm not sure.
Generally, DNAC will not try to any update your device config without permission, especially for interface level configs. There is some interface config done during initial device discovery and site assignment, but otherwise it expects the admins to approve and force config changes using the day-N automation feature. If you have done a provision and the config starts to drift due to manual cli intervention it can flag that as an issue (you will see this as a Compliance Failure in Inventory), but won't try to auto remediate. Things might get a little stricter than that when doing SDA, but it doesn't feel like you are using SDA yet.
