No, it makes no difference. Pickup is 'unsupported' - see the release notes:
http://www.cisco.com/c/en/us/td/docs/voice_ip_comm/cust_contact/contact_center/crs/express_10_5/release/docs/UCCX_BK_UBDB029E_00_uccx-release-notes-105.html#UCCX_TP_L1E5B05A_00
I can tell you want to configure pickup regardless of best practice... so let's do that and you can fix it later on...
Have you added all the agent DNs to the pickup group?
Aaron
Please remember to rate helpful posts to identify useful responses, and mark 'Answered' if appropriate!