The "Use SenderBase for Flow Control" is an option in all Mail Flow Policies, where it is used for SenderBase profiling and mainly for throttling purposes. The AsyncOS maintains counters of connections, messages, recipients, etc, for each connecting IP address. If the IronPort looks up an IP address in SenderBase, one of the attributes it fetches is the size of the block of addresses this address is part of.
For example, if SenderBase states that the CIDR range is 204.15.80.0/22 so by default we will maintain one set of counters for any IP in that range, 204.15.80.1 -204.15.83.254. If SenderBase doesn't return a range, it will default to a /24 mask.
Regards,
Libin