Without firePOWER in picture, can you try sending an email with a file of size 20 MB and see if that's successful. (best way to quickly verify if it's firePOWER issue or some other device in the network).
If without firePOWER it is successful then please let us know a few details:
Do you have file policy inspection enabled? If yes then over which protocols? When you send file with 20MB file what file event you see?
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