So a couple of questions that you can look into-
do you have a proxy for HTTPS traffic? if so, bypass the inspection on the host.
is your access-group statement out on the outside or in on the inside? check the correct ACLs
is the host in the object-group for your destination?
do you have specific ports in an object-group in your crypto acl?
is the address you are trying to hit in your route statement?
can you ping the address?
I would not change the security levels, your acl will determine the traffic that can flow. are you doing nat exempt for the networks you are trying to connect? is your You can try a capture on the inside and outside interfaces to see that your traffic is reaching then natting correctly.
HTH-
Vince