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Great question from @aditya.k.sahu - I am not a Microsoft guy but I recently enabled our company's Microsoft CA to auto-enroll our desktop and laptop machines and user certs via group policy. This works well in this ecosystem and we never have to worry ever again about any of our windows certs expiring, as long as these machines stay domain joined.
That got me thinking - ISE is also domain joined...fair enough, it's not a Windows PC, but there might be some potential to have ISE be managed like a Windows workstation - at least, to enable auto-enrol. Maybe it's too far fetched, but this would be great - at least for the Admin and EAP cert.
For Portal certs it would be great if there were some link to LetsEncrypt to have that cert automatically taken care of. Why should we spend thousands of dollars every year to CA's - those guys just print their own money :-(