Not that work on 4.X. 4.X only supports SCCP endpoints, and there is not one for Mac.
The onbly thing I can think of is to move to 5.X or 6.X which support SIP endpoints and user a 3rd Party SIP softphone for Mac like X-Lite. If you goto 5 or 6 you can also add a Cisco Unified Presence Server and make use of the Cisco Unifed Personal Communicator for Mac, but that gets pricey.