Hello Guy-
I have not worked on those modules yet so I have a few questions/remarks:
1. According to the latest compatibility matrix for ISE, only the following router and switch module combination is supported:
4451-X
SM-X L2/L3 Ethermodule
Now, I am guessing that other router models are supported while the switch module is the critical component. So with that said, can you confirm if your module is SM-X?
Here is the link to the latest compatibility matrix:
http://www.cisco.com/c/en/us/td/docs/security/ise/2-1/compatibility/ise_sdt.html
2. If the module is supported, have you configured the ports to be strict L2 switchports? You would do this by simply entering the "switchport" command under the interface
I hope this helps!
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