1) I believe 10/100 Ethernet uses 4 wires and 1000 Ethernet uses 8 wires. Will the uplink ports connect all 8 of its wires across the 10/100 ports?
Depends. If both uplink ports are 1Gig and you have a Cat5 cable with 2 pairs terminated (4 links) then the speed will only negotiate to 100mbps.
2) Can a 10/100 port connect to another switch using a crossover cable? If so, what happens if a 10/100 port is connected to a 1000 port? Would any damage to the switch occur?
As long as you leave speed and duplex setting to auto and MDI/MDI-X will kick in automatically.