Hello lquin1978,
Signatures normally fire on the presence of data rather than the absence of data. That said, can you provide more detail about what you are trying to accomplish? What L4 protocol are you working with? Are the fields you'd like to match in the header or the payload? Can you provide a packet capture of the traffic scenario in which you would not like the IPS to event, and then specify the packet for which you would like the IPS to event, should that packet go missing?
Thank you,
Blayne Dreier
Cisco TAC Escalation Team
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