So, you are already restricting access to the internet for your users? Or is this a new ASA being setup? In many setups local users will have full access out to the internet so this would not be an issue.
But you could use FQDN in access lists if you are restricting access already...just be sure that the ASA is configured with DNS server IPs so that it can do DNS lookups.
If the above is the case then you could do something like the following:
name-server 192.168.1.1 192.168.1.2 <---configure DNS servers on the ASA
object network SITE1
fqdn b2b.dolgn.net
access-list ACL1 permit tcp any object SITE1 eq 50000
access-group ACL1 in interface inside
Keep in mind that all ACLs have an implicit deny any any at the end of it so if you require your users to access other networks/IPs through the ASA then this must also be permitted in the ACL.
If this is not what you are looking for, please provide a detailed description of your network and exactly what you are trying to acomplish. The more details the better.
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