Do not use the Windows 10 EDGE browser, it wont' work, instead you have to use the IE 11.
IE 11 internet options under the Security tab I have Enable Protected Mode checked on each of the zones. (Internet, Local intranet, Trusted sites, Restricted sites)
If you also want to get rid of the Certificate error when loading VSOM, in the Internet Options, on the Advanced tab also uncheck Warn about certificate address mismatch and then on the address bar while it's red warning about the certificate error. Then when you open VSOM in the browser, click on the certificate shield and click on view certificates, then install certificate then next, choose place all certificates in the following store, choose browse, then select Trusted Root Certification Authorities, then OK and next then Finish. When the security warning comes up, select Yes to install this certificate and then OK on the import was successful. Next time you open VSOM you won't have the certificate warning.
After changes are made you MUST reboot your computer for the settings to fully take effect.
I'd like to give this a try, but for some reason on my Windows 10 machine on IE11, the web login page isn't working at all for VSOM. All I get is the blue page, no login prompt. The page comes up fine in other browsers, but of course the ActiveX stuff won't work on those. Not sure what is going on. Very frustrating though.