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i am unable to remove/update certificate on ISE secondary node.
When i try to edit or remove "portal" setting for the certificate i receive positive pop-up message but certificate is still the same.
In primary node everything is ok.
I believe you need to make change on primary because portal certs gets replicated to all the nodes in the deployment.
Do you have separate portal certificate ?
ps: rate if it helps!!!
Yes, it's replication issue then.
Try to sync up both nodes in cluster which might resolves the issue if you are able to rejoin them again.
ps: rate as correct if it helps!!!!!!