Hello,
I decided to post this fix after searching online for a solution but could not find one except to rebuild ISE.
*****Issue***
ISE will not accept any configuration commands, or application start/stop commands even after restarting several times, or waiting for several hours.
***Error***
ise01/admin# application start ise
Waiting up to 20 seconds for lock: APP_START to complete
Database is still locked by lock: APP_START. Aborting. Please try it later
% Error: Another ISE DB process (APP_START) is in progress, cannot perform Application Start at this time
