Expected Average Client generates roughly 54 queries per day per client.
Take care of WAN links and AMP installation in locations that have limited bandwidth. Deploying many endpoints at one time could impact availability to other network services.
If installing into a location that has bandwidth concerns it may be worth installing a local TETRA Update Server as needed to lessen the demand on the WAN up-link. The TETRA server will act as a local network location for your endpoints to retrieve the necessary updates. This will drastically reduce bandwidth consumption over the WAN link.
Please see AMP Update Server Configuration Steps here: https://www.cisco.com/c/en/us/sup-port/docs/security/amp-endpoints/213237-amp-tetra-on-prem-server-configuration-s.html
ETHOS, SPEROS, DFC and SHA256 Lookup
Unless the bandwidth is extremely limited these engines do not need to be considered as their demand on the network is very limited. The expected traffic volume for a 5,000 Endpoint environment is ~139MB per day.