No, you don't need to do a reload.
If there are no devices logged into the fabric ( show flogi database ) then you will have to do a domain restart.
fcdomain restart vsan xxx
If there are devices logged into the fabric then you will have to do a disruptive domain restart.
This will cause all of the devices to have to log back in to get a new FCID since the domain ID is part of the FCID.
fcdomain restart disruptive vsan xxx
Note: The disruptive keyword is a hidden command.