I have a topology as below. Switch101 and switch102 are vPC peer, and switch201 and switch202 are another vPC peer. All the switches are Nexus 93180-EX HostA is connecting to swtich101 with a orphan port (port-channel) HostB is connecting to switch201/switch202 with vPC link. HostA and HostB are put in the same vPC vlan and well trunked between switches. I'm seeing some strange connection issues. HostA and HostB can't ping each other on ipv6 but OK on ipv4 When I changed the subneting ipv4 (/29 -> /31), ipv6 (/125 -> 127), Ping over ipv6 start working which ping over ipv4 stops. Capture packet showing the ICMP request didn't reach to the other host when pinging which makes me thinking it could be the switch dropping packets somewhere. Any ideas are appreciated! Thank you!