You need the dual NIC option key installed when you're NAT'ing. That doesn't mean you have to use both NICs, but the option key also enables the NAT option on the VCS-E - which you do need.
Take a look at this thread:
https://supportforums.cisco.com/message/3763610#3763610
Note in particular:
"VCS-E must know own IP address to communicate remote device therefore when deploy with NAT configuration, NAT address have to be configured on VCS-E"
/jens
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