I have to update with this simple comment because sometimes the simple things get you in the end. In my case I had everything setup correctly. Nat exempt, split tunneling allowed access to all required networks, and even a nat rule:
nat (inside,outside) source static any any destination static AnyConnect_Pool AnyConnect_Pool no-proxy-arp route-lookup
ASA# show ip System IP Addresses: Interface Name IP address Subnet mask Method GigabitEthernet1/1 outside x.x.x.x 255.255.255.255 CONFIG GigabitEthernet1/2 inside 10.110.0.1 255.255.255.240 CONFIG GigabitEthernet1/3 office 10.110.10.1 255.255.255.224 CONFIG
The problem is the NAT rule, I was able to connect to anything on the inside interface, but because there was a rule that said inside,outside I couldn't get to the office network. Changed the rule to:
nat (any,outside) source static any any destination static AnyConnect_Pool AnyConnect_Pool no-proxy-arp route-lookup
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