Hooooo boy. This is going to be a very, very painful topic.
Right, what kind of RTLS brand?
There are several ways to do RTLS. The most common is using CCX or in "blink mode". Ekahau used to have an RTLS arm until they sold it to Arista in 2016. The tags (please don't get the old models) don't necessarily "associate" to the AP. They have an RTLS mode (CLI command: sh rtls summary).
You'll need "something" for the tags to talk and "display" themselves against a map. So each vendor have their own and this costs considerable amount of money and, depending on what part of the word you're in, time.
Depending on the brand of RTLS tags, they will dictate that the APs power and channel be static (therefore killing the Cisco's "self healing" wireless properties). Because these tags are meant to be operating with tiny batteries, the tags may operate in 2.4 Ghz only and with lowest data rates fully enabled. Aristra is starting to release their new tags that operate in 802.11a but I haven't had the chance to play with them.
If you're playing with RTLS using BLE, we've just started playing with the new Cisco AP4800.