是的,比如如下的示例,没有任何的其他配置,只在R2上互联其他设备的两个物理接口上配置你所提及的两个IP地址,是可以通信的!
R2#sho ip int brief
Interface IP-Address OK? Method Status Protocol
FastEthernet0/0 172.16.10.20 YES manual up up
FastEthernet1/0 192.168.99.182 YES manual up up
R2#
R2#ping 192.168.99.182 so 172.16.10.20
Type escape sequence to abort.
Sending 5, 100-byte ICMP Echos to 192.168.99.182, timeout is 2 seconds:
Packet sent with a source address of 172.16.10.20
!!!!!
Success rate is 100 percent (5/5), round-trip min/avg/max = 1/2/4 ms
R2#