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The best way is to first check for a traceroute to the specific IP address, it will show you the egress interface.
STEP 1.
ASAt# traceroute 53.45.23.1Tracing the route to 53.45.23.1 1 172.24.120.10 0 msec 0 msec 0 msec >> This is your next hop IP 2...
