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Just to add, though it's all coincidental at this point, there was recent case where Microsoft CAB files appear to be "too deep" for Cisco's deep packet inspection algorithms. Apparently, the default behavior is; if the FW cannot inspect the file, it...
It's not a false positive..."it matches a signature". "Whitelist if you believe it's safe". It's not the alert existing that is the problem. Granted I have not seen the surge since but this response from Meraki seems less than helpful.
I can confirm that of 12 sites I have seen this anomaly, 1 "spiked" on Tuesday 6th, the next site was Friday 9th, the other 10 all on Wednesday the 14th. Hope this isn't another "microsoft traffic = BAD" situation. These sites do use Microsoft cloud ...