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After a storage failure, had to recreate a new ISE instance. Upon rebuilding and relicensing, attempting to re-register the node into the distributed deployment (after confirming most up to date version and patch across sites), getting the following ...
Turns out 1/3 DNS servers had a second, old POR for the node in question that was responding first, despite rx'ing the correct response from nslookup in the node. Had to go into the DNS server and delete the old POR. Cert error message resolved right...