Here is the fix: run Microsoft Fix it 51033 to install AppCompat shim per KB 3023607. Thanks to a lead from http://christierney.com/2015/02/11/cisco-anyconnect-failed-to-initialize-connection-subsystem which contains further useful information, go pi...
No luck with the compatibility trick (also not sure why I would want to set this in a different compatibility mode if the program has been running fine for months). My operating system is Windows 8.1 and Cisco client 3.1.05187. I can't tell when this...