I've raised this as TAC case #537158145 and have been told this has been raised as a bug, both against Cisco and Microsoft. Cisco issue is CSCuv74296, and Microsoft bug ID is #4507924 "Cisco AnyConnect PLAP does not work on Windows 10". No ETA for a ...

I'm raising this with Cisco as a TAC case.

I understand what you're saying! We use SBL fine with Windows 7, but not Windows 10. Do Cisco officially support AnyConnect with Windows 10 yet?

I have the same issue with the v4.2.00096 client running on Windows 10 v1511 (Threshold2). If I uninstall the "Start before logon" component, I can lock and unlock without losing the VPN connection.