Hi,
The default gateway can be on ASA or ACE. If it is on ASA, you would need to NAT the traffic so that return traffic also goes through the ACE or you will have asymmetric routing. If ACE is the DGW, you don't need NAT. Some useful links for design:
http://www.cisco.com/c/en/us/td/docs/solutions/Enterprise/Data_Center/ACE_FWSM.html#wp1000603
http://www.cisco.com/c/en/us/products/collateral/application-networking-services/ace-4710-application-control-engine/guide_c07-572616.html
Regards,
Kanwal
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