You can install patch 10 since it is a cumulative patch, there is no need to install all the patches.
You can upgrade from 5.2 to 5.3 via the upgrade tar file that is available in the same download section. You still need to install the latest patch in order to do the upgrade.
If your ACS is a standalone (not distributed) here is the upgrade instructions for a standalone server - http://www.cisco.com/en/US/docs/net_mgmt/cisco_secure_access_control_system/5.3/installation/guide/csacs_upg.html#wp1194871
As always please take a backup (acs backup....) in order to save a recent application backup file in case you have to reimage or thing dont go the way you plan.
Also if you decide to upgrade to 5.3 please install the latest patch, it contains some critical AD fixes.
Thanks,
Tarik Admani
*Please rate helpful posts*