I am not sure your ask here.
Most load balancers are in the same LAN as PSNs or other real servers so that bandwidth between the load balancers and the real servers not an issue.
The other end will be either between the load balancers and NADs or between the load balancers and the endpoints. The most significant might be to perform web deploys from ISE PSNs, because the AnyConnect modules, for example, are sizable.
