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I have a customer that start the journey to the cloud two years ago.
The solution for the perimeter, ISE was selected.
Now after the covid-19, 90% of the workers will continues as teleworker.
60% of the apps are SaaS including office 365.
Today, they don´t see the value of the ISE and the project is in standby.
My question is: is a NAC like ISE still a valid solution if today the perimeter doesn´t exits anymore?.
Please see Cisco's approach to Zero Trust @ https://cisco.com/go/zerotrust which will address your question at an architectural level.
ISE is a AAA server for network users (RADIUS) and network devices (TACACS), wherever they are.
So, yes, still quite valid.