Hello Pramod,
This kind of issues that appear to be random are the more difficults to troubleshoots but that does not mean it cannot be resolved,
My recommendations as usual for this scenarios are:
-Enable logging and send as much logs as possible to a syslog server so we can see the logs at the time of the issue
-Create captures on the ASA on both interfaces ( Inside/Outside) matching HTTP traffic from an specific source and make sure the ASA is the one causing the issue
-What happens if you disable the CSC? does it work?
Regards
Hey Man, remember to rate all of the helpful posts
Julio Carvajal
Senior Network Security and Core Specialist
CCIE #42930, 2xCCNP, JNCIP-SEC