Do a show xlate count and a show conn
do a show perfmon.
see if one of the perfmon counters or other counters look abnormal according to expected patterns in your network.
then do a show conn | grep saA
(displays number of connections in syn state)
a large number indicates problems.
High CPU usually in my experience means a large number of xlates/connections and could possibly be a virus/worm causing a syn attack from internal hosts going out.
65% CPU util is pretty high. What exactly is the PIX you are using and the size of network. I would really open a TAC case if your not experienced in troubleshooting the PIX yet.