phil.jackson@ai-solutions.com  did you get multiple profiles working ? I guess maybe you didn't configure reply URL ( ACS URL) in Azure properly.The  help shows "Patterns: https://YOUR_CISCO_ANYCONNECT_FQDN/+CSCOE+/SAML/SP/ACS" But it should be https...

I have two profiles, but one of them is LDAP.  So you have 5 profiles in same ASA configured with same Azure AD? I would think it shouldn't be a problem.  In each Azure application, you will configure different SP identifier :https://vpn.yourasa.com/...

I had the same problem today, moved a working Cisco anyconnect VPN to a different tenant and got this error. Yes the initial SAML certificate is a weird one and it doesn't work. @ctohang99  , after I switched to the correct certificate, it also didn'...