The only thing that fixed it was re-installing it. I found that my rmuser was an end user not an application user, so checking that may be the fix you are looking for.
I have installed ccx 8.5.1 and cucm 8.5.1 and I am having the same problem with the TUP.ini error message when trying to run the client configuration tool. This is a new install not an upgrade. Any ideas?