Heads Up :
The post you are writing will appear in a public forum. Please ensure all content is appropriate for public consumption. Review the employee guidelines for the community here.
In my experience, 'tcp adjust-mss' will work, but obviously not for non-TCP communications (i.e. UDP / ICMP / other).If you are running applications across your VPNs that do not use TCP (such as TFTP and possibly VoIP) you may need to adjust the MTU ...