Same here...Running Cisco VPN 4.6, worked on 10.13.3, upgraded to 10.13.4 and started receiving the above error " AnyConnect cannot confirm it is connected to your secure gateway. The local network may not be trustworthy. Please try another network.". Anyconnect VPN also failed connection with the same error after formatting and re-installing 10.13.4 (where the Anyconnect VPN client v.4.6 is the ONLY 3rd party software running on it).
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