George-
You probably want to get a tac case open to be sure you don't have any SSL related issues/bugs going on here. However, my ininitial thought was either HTTP parse length is too short for the HTTP header your client may be sending.
Check "show stat http" and look for both of these:
"Max parselen errors" and "Static parse errors"
If you see any, then create an http parameter map and apply it to the class map under the policymap multimatch.
i.e.
parameter-map type http FixMe
set header-maxparse-length 8192
Policy-map multi-match PMM
Class VIP
loadbalance vip inservice
loadbalance policy LBPM
appl-parameter http advanced-options FixMe
Chris