Hi David,
Yes, you can certainly do that.
More details can be found from one of the yesterday's post on CIFS preposition:
"Your PC build files that were part of the preposition job are stored in the CIFS cache within a directory structure which correlates to the specific server (the same goes for on demand CIFS caching as well). So, as you have found if you preposition file A from server X, but then when your client accesses file A from server Y, this will be a CIFS cache MISS (assuming file A wasn't accessed via server A by another client or preposition job). However, you will receive a DRE cache hit, assuming the relevant DRE signatures that represent the bytes for file A have not been aged out."
Hope this helps.
Regards.
PS: Please mark thsi as Answered, if this answers your question.