Hi,
For your setup to be supported, you need to have all of your WAAS devices registered to a Central Manager.
Will it optimise connections if you don't? Yes it will but if you run into any issues with it, you will be on your own...
Regarding the configuration, you need to have the module imported into a CM but you can do all of the config from the CLI if you prefer and only use the CM for statistical reporting.
Nicolas