The CM is the central point in charge of policies, and any customized rules you might have, If you have mixed WAAS versions there could be improvements on the new code that might cause issues where eventually you'll expect traffic rules or WAAS internal processes to fail.
I have not gone through a lab and check the sysreport to make sure no issues will be found on your current deployment but I really doubt there's someone there being so meticulous to verfiy it's performance on a real network, in any case if you had accelerator issues on your network Cisco will probably suggest to upgrade the CM to higher or equal version to the rest peers on the network before going further with troubleshooting.
note:
I recall issues with DRE where some devices where running 4.4..x and the customer had 4..0 on his CM and peers at the same time so yes there are probably some documented issues out there, ending on an upgrade in any case.
cheers,