Interfaces- Only one of the three available Ethernet interfaces on the Cisco appliance is required
for most network environments. However, you can configure two Ethernet interfaces and segregate
your internal network from your external Internet network connection.
Source: ESA_8.0_User_Guide.pdf
You could potentially have low security, high security, and a management interface. Some networks need a physical connection into a dmz but if your environment doesn't need it there is no reason to use multiple interfaces.