We send internal bulk email daily to our O365 users. Our C370D is a relay. Typical emails are around 350KB, today was a few - the smallest one was 40KB ... it filled up the workqueue (+25K) and would only pass around 1000/minute (load balanced across 6 E2010 HUBs - this is not a lot of data so I don't see this being an issue ... it all points to quantity, not volume.
I have been unable to find a Recipient Limit that makes sense. We did set up Destination Controls for this domain (300 concurrent, 500 messages/connection, 10000 recipients/minute, Apply=Entire Domain, Per ESA=System Wide).
Thanks in advance for your recommendations.