I have been running ISE 3.3p2 for a few weeks now and I have not noticed any issues. I have upgraded two separate deployments, each from 3.2p5 to 3.3, using the GUI Split Mode upgrade. No issues with the upgrade either. It's really good now.
Every environment is different, and I will add that the environments I upgraded are not legacy ISE deployments that have been updated from 1.x, to 2.x, etc. They are relatively fresh builds. In my experience, upgrades can fail due to a long history of upgrading the same config.