This is possible. Since it is a vm you will add a NIC for whichever network, login to ISE via cli, and configure the new interface. Then configure a static route for ISE to reach the NADs on the new 10.4.4.x interface. Example from ISE CLI:
Verify NIC is connected/configured: show int g 1
Configure the interface:
conf t
int g 1
ip addr <> <mask>
no shut
Static route example: ip route 10.4.4.x 255.255.255.0 gateway 10.4.4.1
HTH!