Hi Mark,
Profiling is used (generally speaking) for MAB requests, not for 802.1x.
So printers, cameras, anything not supporting 802.1x.
In a nutshell, profiling = check some attributes that ISE receives from NAD, add some points to each attribute/condition, use points to say that the MAC is an "x" device, move MAC into a "x" device group and authorize the session based on that group. (MAC belong to X group = allow or limit access)
https://communities.cisco.com/docs/DOC-68156
Thanks,
Octavian