ROPC is outbound and it can be proxied via proxy setting configured on ISE. ISE can't find the proxy servers via PAC file, and will need to be manually configured with proxy server IP/FQDN:Port.
REST API on TCP/9060 is inbound to ISE, though if the question is whether one can use proxy to reach ISE REST API from a client machine, then the answer is probably will work but have not been tested.