You can easily purge the /var/adm/CSCOpx/log directory using /opt/CSCOpx/bin/logrot.pl. Run logrot.pl -c to configure logfile rotation (add /var/adm/CSCOpx/log/* and that will add all log files).
As for the files subdirectory, this cannot be summarily purged. Yes, you should definitely configure configuration purging under RME > Admin > Config Mgmt > Purge Settings. You will also want to configure a reasonable Change Audit purge schedule for your organization under RME > Admin > ChangeAudit > Set Purge Policy. There is also a /var/adm/CSCOpx/files/rme/dcma/difffiles subdirectory (but DO NOT remove the difffiles directory itself). If you shutdown dmgtd, you can delete all the subdirectories under difffiles, and they will be recreated as needed.