you can configure an ACL something like this to block the smtp traffic:
access-list in_access_out permit tcp host 10.10.10.1 any eq 25
access-list in_access_out permit tcp host 10.10.10.2 any eq 25
access-list in_access_out deny tcp any any eq 25
access-list in_access_out permit ip any any
access-group in_access_out in interface inside